![]() ![]() At this resolution, the reconstructed EM density maps contain sufficient detail to interpret the structure using atomic models. ![]() Major improvements in detector technology ( Faruqi and Henderson, 2007 McMullan et al., 2016) and associated computational procedures recently transformed single-particle cryo-EM that since has been producing a plenitude of near-atomic resolution structures from specimens of lower symmetry ( Allegretti et al., 2014 Amunts et al., 2014 Bai et al., 2013) and lower molecular weight than previously deemed possible ( Bai et al., 2015 Liao et al., 2013 Merk et al., 2016). Electron cryo-microscopy (cryo-EM) has been used as a method to visualize biological macromolecules in their native-hydrated state for more than three decades ( Adrian et al., 1984). ![]()
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